You know I’m always on the lookout for safe, natural supplements that can help improve your health. The key, of course, is that there needs to be actual scientific evidence that these supplements really work.
Unfortunately, that “evidence” can sometimes be nothing more than a couple of questionable studies.
So I was particularly excited recently when I learned about a new supplement that can tackle two of today’s biggest killers—and has reams of clinically significant research behind it.
It’s called oxaloacetate (or OAA). And I’m especially impressed by the research on its brain health benefits. In fact, a recent study shows that OAA can actually help your brain produce new cells.
That means OAA can help the brain repair itself from the ravages of stroke or dementia. In other words, we may be on the verge of finally finding a way to fight Alzheimer’s. Completely naturally, without drugs.
And that’s not all OAA can do. There’s plenty of research showing that this natural compound may help prevent cancer cells from growing and spreading.
But I’ve saved the best for last. OAA has even been proven to mimic the longevity benefits of calorie restriction…without actually having to cut calories.
In essence, OAA may help you live longer…and better. Read on and I’ll tell you how.
Get energized at the cellular level
OAA may sound like some sort of chemical concocted in a lab, but I can assure you it’s totally natural. Also known as oxaloacetic acid, it’s found in apples, dairy products, and fermented foods like yogurt and red wine.1
The body uses OAA to help produce energy at a cellular level. Basically, OAA helps your cells make a substance called adenosine triphosphate, or ATP. And ATP provides the basic energy every cell in your body needs to do its job—whether it’s digesting your breakfast or remembering the name of your sixth-grade teacher.
Unfortunately, as you age, your cells don’t produce ATP as well as they once did. But researchers are learning that you can reverse that energy drain if you have enough of the components your body needs to make ATP—especially OAA.
In fact, one study showed that depriving cells of OAA can cause their energy production to fall by a whopping 500%.2
And OAA can do even more.
Defend your brain
Researchers have discovered it can help flush a neurotransmitter called glutamate out of your body. You need glutamate for learning and memory, but when you have too much, it can become toxic, killing off brain cells. Studies have found too much glutamate can also encourage cancer cells to grow.
And unfortunately, it’s easy for your brain to suffer from glutamate overload. In fact, research shows that stress can send glutamate levels soaring.3
But research shows OAA can flush excess glutamate from your brain in as little as 90 minutes.4
Plus, one recent study shows that OAA has a triple whammy effect directly on brain cells—it helps promote cell energy, reduce the inflammation that can harm cells, and actually create new cells.5
Two independent clinical studies also show that OAA’s ability to reduce glutamate can significantly improve neurological performance and function in people who have had a stroke.6
There is currently research underway to see if OAA can be effective at preventing or lessening the effects of Alzheimer’s disease.7 I’m anxiously awaiting the results and will keep you posted.
Live 25% longer
I’ve told you before how restricting calories can increase your lifespan and help fight off serious diseases like cancer, Alzheimer’s, Parkinson’s, and diabetes.
In a study on worms, researchers found that OAA can have the same effects, but without reducing calories.8 In fact, the worms given OAA lived an average of 25% longer than those that didn’t take OAA.
There have been other OAA longevity trials on animals that show equally impressive results. Of course, none of this is the same as research on people. But because humans live so long, a study on OAA’s longevity effects will take decades before it’s finished. In the meantime, the animal research appears quite promising.
Fight cancer 237% more effectively
Glutamate can play a role in the growth of malignant brain tumors known as gliomas. And it also helps other types of cancer cells grow and divide.9
So it makes sense that by reducing the levels of glutamate in your body, OAA can help you fight the development and spread of cancer.
In fact, research shows that mice with gliomas that were given OAA had a 237% better survival rate than the ones not given OAA.10
How much do you need and where can you find it?
I mentioned above that OAA can be found in certain foods. But only in small amounts—not the 100-250 mg daily that’s been proven in studies to be effective. That’s why I recommend OAA supplements.
There are only a few companies that market OAA supplements. If you can’t find it at your local nutritional supplement store, you can buy it via the Internet. (You can track down retailers offering it by doing a quick Google search.)
Look for formulas that use thermally stabilized OAA because OAA is notoriously volatile. If it’s not thermally stabilized, it has to be stored at ultra-freezing temperatures to ensure it stays safe and effective. OAA is usually combined with vitamin C, which helps further stabilize it.
1“Rapid and accurate determination of malate, citrate, pyruvate and OAA by enzymatic reactions coupled to formation of a fluorochromophore: Application in colorful juices and fermentable food (yogurt, wine) analysis.” Food Chemistry Volume 129, Issue 2, 15 November 2011, Pages 608–613.
2“Pyruvate dehydrogenase activity in osmotically shocked rat brain mitochondria: stimulation by OAA.” J Neurochem. 1988 Mar;50(3):673-80.
3“The stressed synapse: the impact of stress and glucocorticoids on glutamate transmission.” Nature Reviews Neuroscience 13, 22-37 (January 2012).
4“The Effect of Blood Glutamate Scavengers OAA and Pyruvate on Neurological Outcome in a Rat Model of Subarachnoid Hemorrhage.” Neurotherapeutics. 2012 Jul; 9(3): 649–657.
5“OAA supplementation increases lifespan in Caenorhabditis elegans through an AMPK/FOXO-dependent pathway.” Aging Cell Volume 8, Issue 6, pages 765–768, December 2009.
6“High blood glutamate OAA transaminase levels are associated with good functional outcome in acute ischemic stroke.” J Cereb Blood Flow Metab. 2011 Jun;31(6):1387-93.
8“OAA activates brain mitochondrial biogenesis, enhances the insulin pathway, reduces inflammation and stimulates neurogenesis.” Hum Mol Genet. 2014 Dec 15;23(24):6528-41.
9“Glutamine Addiction: A New Therapeutic Target in Cancer.” Trends Biochem Sci. 2010 Aug; 35(8): 427–433.
10“Blood glutamate scavengers prolong the survival of rats and mice with brain-implanted gliomas.” Invest New Drugs. 2012 Feb 2.